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KMID : 1007520220310131661
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Food Science and Biotechnology
2022 Volume.31 No. 13 p.1661 ~ p.1666
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The analysis of 2′-fucosyllactose concentration in Korean maternal milk using LC?MS/MS
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Nguyen My Tuyen T.
Seo Na-Ri
Kim Yong-Ki
Jung Ji-A.
An Hyun-Joo
Kim Jung-Min
Song Young-Ha
Kim Jae-Han
Yoon Jong-Won
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Abstract
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Despite health benefits reported recently, 2′-fucosyllactose (2′-FL) concentration in maternal milk was not conclusively reported because it varies between countries and mothers. Particularly, its distribution among Korean mothers was not obtained from a reliable sample group yet. Thus, a dynamic range for 2′-FL concentration in Korean mothers’ milk was investigated from 102 samples. A quantitative method using multiple reaction monitoring (MRM) by triple-quadrupole-mass spectrometry has been evaluated by a standard procedure of method validation. The 2′-FL concentration was in the range of 0.4 to 2.6 g/L overall. While the samples from secretor mothers (n?=?80) contained 1.0 to 2.8 g/L of 2′-FL, the maternal milk from non-secretor mothers (n?=?22) had 0.01 to 0.06 g/L of 2′-FL only. In addition to the genetic variation of mothers, the lactation period impacted the 2′-FL concentration. The average 2′-FL concentration of the late-stage group (>?60 days) was 78% of that obtained from the first month of postpartum mothers.
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KEYWORD
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2′-Fucosyllactose, Human milk, Quantification, Human milk oligosaccharides (HMOs), Mass spectrometry
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